Spotlight

Insights

Nimacimab Promotes Metabolic Homeostasis

ADA poster highlights nimacimab’s weight loss and metabolic improvements including enhanced body composition, metabolic restoration, and improved hormonal profile in diet-induced obesity model.

Released June 23, 2025

Diet-induced Obesity Model Weight Loss and Biomarker Data

Obesity conference presentation notes nimacimab’s differentiation, weight loss data from preclinical obesity model, and new biomarker data showing reduction in obesity-induced inflammation and liver steatosis.

Released June 22, 2025

Revisiting the Potential Role of a Restricted CB1 Inhibitor

This update highlights Skye’s progress in obesity drug development, noting the differentiation of its allosteric modulating antibody that takes into consideration fat metabolism, safety and long-term care.

Released June 20, 2025

Nimacimab: Designed to Offer Distinct Capabilities

This article characterizes Skye’s highly peripherally-restricted CB1 inhibitor and its advantages relative to the incretin class of anti-obesity drugs and small-molecule CB1 inhibitors, with recent preclinical data.

Released June 20, 2025

Assessing the Effect of Nimacimab’s Mechanistic Differences

CB1 inhibition offers the prospect of modulating mechanisms complementarily to incretins. Skye's CBeyond Phase2a trial is assessing its CB1 inhibitor's weight loss effects in monotherapy and combination arms.

Released June 20, 2025

Considering the Opportunity for a Differentiated Target Product Profile

Obesity physicians frame the opportunity for a non-GLP1 obesity therapeutic with the target product profile of a peripherally-inhibited CB1 inhibitor such as nimacimab.

Released June 20, 2025

Preclinical Models Highlight Utility of Peripheral CB1 Inhibition

Pharmacokinetic and pharmacodynamic models highlight the utility and sufficiency of peripherally-targeted versus central CB1 inhibition.

Released May 13, 2025

KOLs Discuss Potential of Non-GLP1 Mechanism for Metabolic Rewiring

New preclinical data highlight dose-dependent weight loss along with insights from KOLs regarding peripheral vs centrally-driven CB1 inhibition.

Released November 5, 2024

Obesity Specialists Weigh in on Need for New Anti-obesity Drugs

Skye and key opinion leaders offer insights into unmet treatment needs related to obesity, and the potential role of a next-generation CB1 inhibitor.

Released July 24, 2024